These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Analysis of lidocaine on the COBAS INTEGRA.
    Author: Liu-Allison LY, Hui RA, Schwenzer KS.
    Journal: Ann Clin Lab Sci; 1997; 27(2):105-15. PubMed ID: 9098509.
    Abstract:
    A new fluorescence polarization (FP) immunoassay was developed for the COBAS INTEGRA to quantitate lidocaine in serum and sodium heparin derived plasma. The COBAS INTEGRA, a random and continuous access clinical analyzer, performs the new lidocaine assay at a throughput of 300 tests per hour. Comparison studies with the Abbott TDx Lidocaine assay yielded a correlation coefficient of 0.99 and a regression value of INTEGRA = -0.01 + 0.95 TDx, n = 69. The assay was found to be linear throughout the concentration range of 0 to 10 micrograms/ml using CASCO STANDARDS's DOCUMENT TDM 1 Linearity Test Set and the COBAS-FP TDM Calibration Verification Test Set. The new lidocaine assay exhibited good precision as determined by the National Committee for Clinical Laboratory Standards (NCCLS) protocol EP5-T2 with total percent coefficient of variation (%CV) values of less than 4 percent across the assay range. Interference was less than 10 percent for abnormal levels of total protein (2.1 to 10 g/dl), lipid (up to 2200 mg/dl triglyceride), hemoglobin (up to 10 g/dl), and icteric samples (up to 17.5 mg/dl bilirubin). Finally, the standard curve was stable for greater than 25 weeks which was attributable to the on-board reagent cooling and a unique cassette closure system.
    [Abstract] [Full Text] [Related] [New Search]