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  • Title: Long-term potentiation and depression in layer III and V pyramidal neurons of the cat sensorimotor cortex in vitro.
    Author: Kitagawa H, Nishimura Y, Yoshioka K, Lin M, Yamamoto T.
    Journal: Brain Res; 1997 Mar 21; 751(2):339-43. PubMed ID: 9099825.
    Abstract:
    Synaptic plasticity of the cat sensorimotor cortex was examined intracellularly in vitro. After tetanic stimulation of the white matter, layer III and V pyramidal neurons showed long-term potentiation (LTP) of EPSPs in high incidence without GABA(A) antagonist. The incidence and magnitude of LTP were very conspicuous in layer V cells. After an NMDA receptor antagonist application, the synaptic potentiation was blocked completely in layer III but not in layer V cells. Long-term depression (LTD) of the evoked EPSPs was also induced by the same stimulation in some layer III cells, where a transient hyperpolarization of the membrane potential was observed during tetanus.
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