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  • Title: [Hepatic veno-occlusive disease--simulating acute abdomen in chemotherapy of Wilms' tumors].
    Author: Tröbs RB, Rothe K, Meier T.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1996; 113():1112-4. PubMed ID: 9101794.
    Abstract:
    Two of fifteen patients treated in the last 5 years in our hospital for malignant renal tumors developed a venoocclusive disease (VOD). Both had stage II Wilms' tumors with favorable histology. The VOD occurred in the pre- and postoperative period, respectively, some days after application of vincristine and dactinomycin. The boys were aged 2 years and 3 months and 2 years and 9 months, respectively, with body weights of 13 kg and 19 kg, respectively. The treatment of VOD required intensive care procedures. The tumours were removed by nephrectomy and the patients have now remained in remission for 3 years and 1 year and 4 months, respectively. Jaundice, enlargement of the liver, ascites and fever were the symptoms in both patients. Initially, the VOD presented like appendicitis.
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