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  • Title: [Surgical procedure in children with medullary thyroid gland carcinoma with reference to multiple endocrine neoplasia type II].
    Author: Schäfer K, Senninger N, Roth H, Buhr HJ.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1996; 113():202-4. PubMed ID: 9101831.
    Abstract:
    Between 1988 and 1995 we treated ten patients aged 7-18 years for familial MTC or MEN II syndrome with a total of 17 operations. Using these surgical procedures, 6/9 patients remained free of tumor after 0-8 years (mean 4.5 years). In conclusion, we recommend thyroidectomy [1] in children younger than 5 years of age and a family history of MEN IIa; [2] in children younger than 3 years of age, presenting the characteristic phenotype of MEN IIb, both with a positive test for mutation of the RET protooncogene [4].
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