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  • Title: [Oncologic surgery of malignancies in childhood. Effect of adjuvant/neoadjuvant methods].
    Author: Mildenberger H.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1996; 113():76-9. PubMed ID: 9101984.
    Abstract:
    Pre- and/or postoperative chemotherapy is highly effective in the treatment of pediatric malignancies and has modified surgical strategies significantly. (1) In childhood abdominal Non-Hodgkin-Lymphomas early chemotherapy has a definite priority over extended excisions. (2) In hepatoblastomas, radical excision is essential for effecting a cure. However, in the case of an advanced tumor, it is wise to start treatment with chemotherapy and then to perform surgery. (3) Pre-operative chemotherapy in Wilms' tumors effects a "down staging", which allows therapy reduction and omission of postoperative radiotherapy in the majority of cases.
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