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  • Title: Induction of aldose reductase and xylitol dehydrogenase activities in Candida tenuis CBS 4435.
    Author: Kern M, Haltrich D, Nidetzky B, Kulbe KD.
    Journal: FEMS Microbiol Lett; 1997 Apr 01; 149(1):31-7. PubMed ID: 9103975.
    Abstract:
    In this study the ability of various sugars and sugar alcohols to induce aldose reductase (xylose reductase) and xylitol dehydrogenase (xylulose reductase) activities in the yeast Candida tenuis was investigated. Both enzyme activities were induced when the organism was grown on D-xylose or L-arabinose as well as on the structurally related sugars D-arabinose or D-lyxose. Mixtures of D-xylose with the more rapidly metabolizable sugar D-glucose resulted in a decrease in the levels of both enzymes formed. These results show that the utilization of D-xylose by C. tenuis is regulated by induction and catabolite repression. Furthermore, the different patterns of induction on distinct sugars suggest that the synthesis of both enzymes is not under coordinate control.
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