These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7.
    Author: Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D.
    Journal: Brain Res Mol Brain Res; 1997 Apr; 45(1):145-8. PubMed ID: 9105682.
    Abstract:
    A human tryptophan hydroxylase intron seven polymorphism previously associated with low CSF 5-HIAA and suicidal behavior was sequenced and characterized for its potential role in TPH pre-mRNA splicing. Two polymorphic sites were identified: A218C and A779C. The 779A allelic frequency in various populations ranged from 0.43 to 0.61 and was in strong linkage disequilibrium with the A218C site. A218C provides a site for restriction fragment length polymorphism analysis. TPH mRNA was reverse-transcribed and sequenced. No aberrant splice products from the 779A or 779G TPH genes were detected nor were any other polymorphic nucleotides found.
    [Abstract] [Full Text] [Related] [New Search]