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  • Title: Malignant change in an intradiploic epidermoid cyst.
    Author: Hoeffel C, Heldt N, Chelle C, Claudon M, Hoeffel JC.
    Journal: Acta Neurol Belg; 1997 Mar; 97(1):45-9. PubMed ID: 9107345.
    Abstract:
    We describe a unique case of an intra-diploic epidermoid cyst of the parietal and occipital right bone in a 43 year-old man. The tumor remained quiescent for 12 years and then spontaneously showed malignant changes with intra-cerebral involvement. Fatal outcome occurred one year after surgery, radiation therapy and chemotherapy because of a recurrence. Malignant transformation of the epithelium in epidermoid cyst is very rare. Our case is the first one where this transformation occurred spontaneously without previous surgery.
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