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  • Title: Evaluation of ketorolac in children with forearm fractures.
    Author: Pierce MC, Fuchs S.
    Journal: Acad Emerg Med; 1997 Jan; 4(1):22-6. PubMed ID: 9110007.
    Abstract:
    OBJECTIVES: To evaluate ketorolac for pain relief and an opioid-sparing effect in children with forearm fractures necessitating reduction. METHODS: A prospective, randomized, double-blind study was conducted at an urban children's hospital ED. A convenience sample of children aged 3-18 years with isolated forearm fractures was studied. None received prior pain medication. A 10-point visual analog scale (VAS) was used to assess pain at the time of study entry and prior to sedation/analgesia. The Children's Hospital of Eastern Ontario's Pain Score (CHEOPS), a 13-point behavioral score, was used to assess pain during sedation. Patients received either IV ketorolac (K), 1 mg/kg, or saline (S) after entry into the study. After a minimum of 20 minutes, pain was reassessed and supplemental analgesia/sedation administered. A standard dose of midazolam, 0.1 mg/kg to a maximum of 6 mg, was given to all patients, and fentanyl was titrated at 1-microgram/kg increments based on patient need. Once the patient was comfortable, reduction was performed and a reduction CHEOPS score assigned. RESULTS: For the 34 study children (17 K, 17 S), there was no difference in sex or mean age between the groups. Mean total doses of fentanyl were 2.26 micrograms/kg in the K group and 2.85 micrograms/kg in the S group (p = 0.07). The median changes in VAS score before and after receiving the study drug were -1.13 K and -0.18 S (p = 0.06). The median CHEOPS score was 10 for both groups. Seven of the 17 patients in the S group required the maximum fentanyl dose (4 micrograms/kg), compared with 2 of 17 in the K group (p = p.06). CONCLUSIONS: Although ketorolac seems to add to patient comfort in children with forearm fractures, it does not have a significant opioid-sparing effect. Ketorolac showed a trend toward pain relief, but statistical significance was not reached.
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