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  • Title: Effect of ketoconazole 2% shampoo on scalp sebum level in patients with seborrhoeic dermatitis.
    Author: Dobrev H, Zissova L.
    Journal: Acta Derm Venereol; 1997 Mar; 77(2):132-4. PubMed ID: 9111824.
    Abstract:
    Twenty patients with scalp seborrhoeic dermatitis were treated twice weekly with ketoconazole 2% shampoo for 4 weeks. Clinical assessment, culture for P. ovale on Dixon broth and lipid measurement at two places were made before treatment and after 2 and 4 weeks. Significant improvement of the severity of seborrhoeic dermatitis (p < 0.001) and negative mycological tests by 19 (95%) of patients were observed. The scalp lipid content remained unaltered in 11 patients with an initial lipid value over 220 micrograms/cm2 but increased in those with lower initial values. This is probably due to the improvement of sebum delivery onto skin surface as a result of the elimination of the follicular occlusion.
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