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  • Title: Inhibitory action of reveromycin A on TGF-alpha-dependent growth of ovarian carcinoma BG-1 in vitro and in vivo.
    Author: Takahashi H, Yamashita Y, Takaoka H, Nakamura J, Yoshihama M, Osada H.
    Journal: Oncol Res; 1997; 9(1):7-11. PubMed ID: 9112255.
    Abstract:
    The antitumor effect of reveromycin A (RM-A), an inhibitor of EGF-dependent cell proliferation on murine and human tumor cell lines, was examined in vitro and in vivo, RM-A showed little antitumor effect against three murine tumors tested, but showed strong antitumor effect (a minimum treated/control ratio of 36%) against a human ovarian carcinoma BG-1, which is known to be a transforming growth factor alpha (TGF-alpha)-secreting and estrogen receptor-expressing cell line. In BG-1 cells, RM-A inhibited the cell proliferation induced by TGF-alpha at the concentration range 30-300 nM, but did not inhibit the proliferation induced by 17 beta-estradiol (E2).RM-A is a possible new antitumor drug with a novel mechanism of action and may also be a useful tool for the analysis of epidermal growth factor receptor (EGFR)-mediated cell proliferation in tumor cells.
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