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  • Title: Neuroimaging of AIDS. I. Viral infections.
    Author: Lizerbram EK, Hesselink JR.
    Journal: Neuroimaging Clin N Am; 1997 May; 7(2):261-80. PubMed ID: 9113690.
    Abstract:
    Viral infections of the brain and spinal cord cause significant morbidity and mortality in patients afflicted with AIDS. Debate continues over the specific mechanisms and pathways of how HIV-1 manifests itself in the brain and spinal cord. Attempts to predict which seropositive patients develop neurocognitive deficits caused by HIV-1 and how soon these deficits will occur in the course of disease have had limited success. The neuropathologic changes of HIV-1 must be distinguished from other viral infections, such as cytomegalovirus, JC papovavirus (progressive multifocal leukoencephalopathy), herpes simplex virus type 1, and varicella-zoster virus. In addition to cerebral spinal fluid sampling and serum testing, some specific features are seen with contrast-enhanced CT, MR imaging, proton MR spectroscopy, SPECT, and PET.
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