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  • Title: Autoradiographic localization of receptors for neuropeptide Y (NPY) in the brain of broiler and leghorn chickens (Gallus domesticus).
    Author: Merckaert J, Vandesande F.
    Journal: J Chem Neuroanat; 1996 Dec; 12(2):123-34. PubMed ID: 9115667.
    Abstract:
    Broiler and leghorn chickens show an extreme difference in ingestive and reproductive behavior. As neuropeptide Y (NPY) influences both behaviors the goal of this study was to elucidate the distribution, expression and affinity of NPY binding sites in broiler and leghorn chicken brain. By means of in vitro autoradiography, sections of chicken brains were incubated with 3H-NPY as tracer and NPY as displacer. Scatchard analysis revealed a curvilinear plot suggesting two subtypes of the NPY binding site in the chicken brain, a high affinity one (KD = 2-4 nM) and one with a lower affinity (KD = 18-24 nM). Binding sites for NPY are localized with high density in the different subdivisions of the neostriatum and the hyperstriatum, the cerebellum, the nucleus septalis lateralis and medialis, the nucleus ruber and the nucleus tractus solitarii. A lower density of NPY binding sites was found in the different subdivisions of the striatum, the nucleus mesencephalicus lateralis pars dorsalis, the paleostriatum, the archistriatum intermedium pars ventralis, the nucleus geniculatus lateralis, the nucleus taeniae, the locus ceruleus, the nucleus rotondus, the nucleus habenularis medialis, the nucleus dorsomedialis anterior (rostralis) thalami, the pituitary and the area of the hypothalamus with its nuclei such as the nucleus paraventricularis magnocellularis and the nucleus preopticus medialis. Comparison of the localization of NPY binding sites in the brains of broilers and leghorns showed no differences but the density of both receptor types is two to three times higher in broilers than in leghorns.
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