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  • Title: Ramipril-associated lichen planus pemphigoides.
    Author: Ogg GS, Bhogal BS, Hashimoto T, Coleman R, Barker JN.
    Journal: Br J Dermatol; 1997 Mar; 136(3):412-4. PubMed ID: 9115928.
    Abstract:
    We report the first case of lichen planus pemphigoides (LPP) secondary to ingestion of ramipril, an angiotensin-converting enzyme inhibitor. Clinical, histological and immunofluorescent findings were all consistent with a diagnosis of LPP. Linear basement membrane zone (BMZ) staining with IgG and C3 was only seen at the roof of split-skin preparations and circulating autoantibody to the BMZ was present at a titre of 1/100. Controlled immunoblotting of epidermal extracts detected the bullous pemphigoid antigens of 230 and 180 kDa.
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