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  • Title: Protection against non-NMDA receptor-mediated excitotoxicity by GYKI 52466 in mature telencephalic cultures of the rat.
    Author: Kovács AD, Egyed A.
    Journal: Neurobiology (Bp); 1996; 4(1-2):59-72. PubMed ID: 9116695.
    Abstract:
    The neuroprotective effect of 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI 52466), a recently developed non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate antagonist was demonstrated against quisqualate (10 or 15 microM) and AMPA (20 microM) excitotoxicity in mature (17-20 days in vitro) cultures of rat embryonic telencephalic cells. GYKI 52466 attenuated quisqualate (15 microM) or AMPA (20 microM) neurotoxicity in a dose-dependent manner with IC50 of 16 microM and 10 microM, respectively.
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