These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mast cell numbers are increased in the smooth muscle of human sensitized isolated bronchi.
    Author: Ammit AJ, Bekir SS, Johnson PR, Hughes JM, Armour CL, Black JL.
    Journal: Am J Respir Crit Care Med; 1997 Mar; 155(3):1123-9. PubMed ID: 9116997.
    Abstract:
    The aim of this study was to examine the process underlying the increase in responsiveness of human bronchus related to sensitization status by examining inflammatory cells in sensitized and nonsensitized tissue. Sensitization status was determined in tissue from 26 subjects by detecting the presence or absence of contraction of bronchial rings to common Australian allergens. Serial sections (6-micron) of bronchial tissue were stained for mast cells, T lymphocytes, and eosinophils. There was no significant difference between the total number of inflammatory cells present in all locations (to a depth of 0.5 mm) of nonsensitized (n = 14) and sensitized (n = 12) bronchi. Similar numbers of cells were present in the two patient groups in epithelium, lamina propria, and adventitia. In contrast, there were significantly (p = 0.03) more inflammatory cells present within the smooth muscle of sensitized bronchi. A significantly (p = 0.04) greater number of mast cells in sensitized (9 [2-14]) versus nonsensitized (2[0-8]) tissue was found in this location (data are median with first and third quartile range). In addition there was a trend toward a greater area of smooth muscle in sensitized tissue. There results suggest that an interaction between smooth muscle and inflammatory cells, especially mast cells, may play a role in bronchial hyperresponsiveness in vitro.
    [Abstract] [Full Text] [Related] [New Search]