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  • Title: Lysosomal membrane stabilization by alpha-tocopherol against the damaging action of Vipera russelli venom phospholipase A2.
    Author: Mukherjee AK, Ghosal SK, Maity CR.
    Journal: Cell Mol Life Sci; 1997 Feb; 53(2):152-5. PubMed ID: 9118003.
    Abstract:
    This investigation shows the membrane stabilizing effect of alpha-tocopherol against the damaging action of viper venom phospholipase A2 (PLA2). Liver lysosomal membranes from rats fed 100 mg and 200 mg alpha-tocopherol acetate per kilogram of diet were more resistant to damage by viper venom PLA2 compared with vitamin E-deficient rats. The membrane stabilizing effect of vitamin E is proposed to be due to the formation of a complex with the phospholipid hydrolysis products of the membrane.
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