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  • Title: The effects of thromboxane B2 and 6-ketoprostaglandin F1alpha on cultured fibroblasts.
    Author: Murota SI, Morita I, Abe M.
    Journal: Biochim Biophys Acta; 1977 Nov 02; 479(1):122-5. PubMed ID: 911847.
    Abstract:
    The effects of thromboxane B2 and 6-ketoprostaglandin F1alpha on the synthesis of DNA, RNA and hexosamine-containing substances were studied. Thromboxane B2 (1 microgram/ml) added to cultures in the stationary phase caused the initiation of DNA synthesis and cell proliferation in a small proportion of cells. The same amount of thromboxane B2 also increased [3H]uridine incorporation into acid-insoluble fraction by 50% in 24 h, and stimulated the production of hexosamine-containing substances 2.5 fold over the control during the first 6 h. On the other hand, 6-ketoprostaglandin F1alpha was essentially inactive on these indexes except slight stimulation of DNA synthesis.
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