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  • Title: Effect of prolactin on in vitro expression of the bovine mammary immunoglobulin G1 receptor.
    Author: Barrington GM, Besser TE, Gay CC, Davis WC, Reeves JJ, McFadden TB.
    Journal: J Dairy Sci; 1997 Jan; 80(1):94-100. PubMed ID: 9120100.
    Abstract:
    Explants of mammary tissue from cows in late pregnancy were incubated for 72 h in serum-free, hormonally defined media to investigate the regulation of the bovine mammary IgG1 receptor. Treatments included incubation in basal medium alone, basal medium plus estradiol-17 beta, basal medium plus prolactin, or basal medium plus estradiol-17 beta and prolactin. alpha-Lactalbumin production was measured by radioimmunoassay in culture supernatants collected at 24, 48, and 72 h. Explants were examined immunohistochemically for expression of the IgG1 receptor at 24, 48, and 72 h. alpha-Lactalbumin concentrations increased, and IgG1 receptor expression decreased, by 72 h with explants cultured in the medium containing prolactin. Results suggest that, in addition to its positive lactogenic effect, prolactin decreases expression of the bovine mammary IgG1 receptor.
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