These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The urokinase receptor and cell migration.
    Author: Blasi F.
    Journal: Semin Thromb Hemost; 1996; 22(6):513-6. PubMed ID: 9122717.
    Abstract:
    The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasminogen. Regulation of the activity of u-PA is also mediated by u-PAR. In fact, while active u-PA is not internalized or degraded, rather remaining active at the cell surface, serpin-inactivated u-PA is internalized, through the intervention of a second molecule, the alpha 2-macroglobulin receptor (LRP). In the process u-PAR too is internalized and possibly recycles back to the cell surface. In addition, u-PAR occupancy can also directly transduce migratory signals, like chemotaxis, that do not require the protease activity of u-PA. Occupancy of u-PAR activates tyrosine kinases, in particular of p56/p59hck, through an as yet undefined transmembrane adaptor.
    [Abstract] [Full Text] [Related] [New Search]