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  • Title: Orbital avitene granuloma formation after enucleation for intraocular retinoblastoma.
    Author: Abramson DH, Andracchi S.
    Journal: Am J Ophthalmol; 1997 Apr; 123(4):567-9. PubMed ID: 9124265.
    Abstract:
    PURPOSE: To report a case of orbital foreign body granuloma formation, mimicking tumor recurrence, secondary to the use of Avitene after enucleation for intraocular retinoblastoma. METHODS: Eight months after undergoing enucleation for retinoblastoma, a 21-month-old boy underwent a biopsy of an orbital mass. RESULTS: Histopathologic examination of the orbital biopsy specimen disclosed a proliferative granulomatous foreign body reaction surrounding multiple foci of a coarse fibrillar intercellular substance consistent with Avitene. No retinoblastoma cells were present. CONCLUSION: A foreign body reaction should be included in the differential diagnosis of orbital mass lesions after surgery in which Avitene is used.
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