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  • Title: Treatment of enteric fever with pefloxacin for 7 days versus 5 days: a randomized clinical trial.
    Author: Unal S, Hayran M, Tuncer S, Gür D, Uzun O, Akova M, Akalin HE.
    Journal: Antimicrob Agents Chemother; 1996 Dec; 40(12):2898-900. PubMed ID: 9124864.
    Abstract:
    In this prospective study of enteric fever, 22 patients received 400 mg of pefloxacin twice daily for 5 days (group A) and 24 received 400 mg of pefloxacin twice daily for 7 days (group B). Causative microorganisms were Salmonella typhi (8 in group A, 11 in group B) and Salmonella paratyphi B (14 in group A, 13 in group B). The clinical cure and bacterial eradication rates were 96% (21 of 22) in group A and 100% in group B. In conclusion, 5-day oral administration of pefloxacin was as effective as 7-day treatment of enteric fever caused by Salmonella spp.
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