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  • Title: delta 9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus.
    Author: Corchero J, Fuentes JA, Manzanares J.
    Journal: Eur J Pharmacol; 1997 Apr 04; 323(2-3):193-5. PubMed ID: 9128838.
    Abstract:
    delta 9-Tetrahydrocannabinol, the main psychoactive component of cannabis, produces a large spectrum of pharmacological effects, many of which have been linked to interaction with the opioid system. The aim of this study was to examine the effects of delta 9-tetrahydrocannabinol on proopiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus and anterior lobe of the pituitary. We report, for the first time, that a 5-day treatment with delta 9-tetrahydrocannabinol (5 mg/kg per day, i.p.) increased (38%) POMC mRNA levels in the arcuate nucleus of the hypothalamus but was without effect in the anterior lobe of the pituitary. These data indicate that delta 9-tetrahydrocannabinol stimulates opioid gene expression and regulates distinctively POMC in the hypothalamus and the anterior lobe of the pituitary in the rat.
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