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  • Title: delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain.
    Author: Burkey TH, Quock RM, Consroe P, Roeske WR, Yamamura HI.
    Journal: Eur J Pharmacol; 1997 Apr 04; 323(2-3):R3-4. PubMed ID: 9128853.
    Abstract:
    We measured the ability of the cannabinoid agonists delta 9-tetrahydrocannabinol and R(+)-[2,3,-dihydro-5-methyl-3- [(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-napht halenyl) methanone mesylate (WIN 55,212-2) to stimulate guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTP gamma S) binding in mouse brain membranes. delta 9-Tetrahydrocannabinol stimulated [35S]GTP gamma S binding by about 25% as compared to WIN 55,212-2. This is the first report demonstrating that delta 9-tetrahydrocannabinol acts as a partial agonist in stimulating [35S]GTP gamma S binding in the mouse brain.
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