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  • Title: Schizophrenia and chromosome 6p.
    Author: Turecki G, Rouleau GA, Joober R, Mari J, Morgan K.
    Journal: Am J Med Genet; 1997 Apr 18; 74(2):195-8. PubMed ID: 9129723.
    Abstract:
    Several studies have recently reported genetic linkage between markers located on the short arm of chromosome 6 and schizophrenia. Valid conclusions, however, are difficult to formulate because chromosomal markers that yielded positive results span a relatively large region of chromosome 6, and studies did not necessarily obtain consistent results with regard to the particular loci tested. Here, we report a meta-analysis of the results of linkage studies of schizophrenia that used chromosome 6p markers. After conducting a systematic search, nine different studies were selected for the analysis using defined criteria. Pooled P values were obtained for all common markers investigated and provided additional support for a major susceptibility locus for schizophrenia in this region. In addition, two markers located 2 cM apart, D6S274 and D6S285, provided the most significant results. These findings may help narrow the chromosomal region in the search for a major gene implicated in schizophrenia.
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