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  • Title: Low doses of 1,25-dihydroxycholecalciferol increase mature bone mass in adult normal rats.
    Author: Larsson SE, Lorentzon R, Boquist L.
    Journal: Clin Orthop Relat Res; 1977; (127):228-35. PubMed ID: 912986.
    Abstract:
    Low doses of 1,25-DHCC cause a significant increase in trabecular and cortical bone mass of the mature rat skeleton by stimulated endosteal bone formation. The increased serum contents of calcium and inorganic phosphate give rise to a moderate nephrocalcinosis. An increased bone resorption occurs upon toxic dose levels causing profound nephrocalcinosis. Similar doses of 25-HCC do not affect the mature bone.
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