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  • Title: E cadherin expression in normal and neoplastic canine mammary gland.
    Author: Restucci B, Papparella S, De Vico G, Maiolino P.
    Journal: J Comp Pathol; 1997 Feb; 116(2):191-202. PubMed ID: 9131434.
    Abstract:
    The epithelial intercellular adhesion molecule, E cadherin, was evaluated immunohistochemically in a series of normal and malignant neoplastic canine mammary glands. The normal glands showed strong immunolabelling at the intercellular borders of all the ductal cells. Tubular and papillary mammary adenocarcinomas had reduced intercellular E cadherin positivity with "heterogeneous" or "cytoplasmic" distribution. Solid and squamous cell carcinomas were negative. These results suggest that reduced expression and abnormal distribution of E cadherin may be related to the differentiation grade of these neoplasms.
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