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  • Title: [Determination of intercellular adhesion molecule-1 (ICAM-1) in nasal secretions of patients with rhinitis].
    Author: Bujía J, Rasp G.
    Journal: Acta Otorrinolaringol Esp; 1997; 48(1):11-4. PubMed ID: 9131919.
    Abstract:
    Intercellular adhesion molecule-1 (ICAM-1) is an integrin involved in the regulation of cell migration and activation in various tissues. ICAM-1 expression has been shown to be associated closely with cell infiltration in allergic diseases. We analyzed the possible participation of soluble ICAM-1 (sICAM-1) in the pathogenesis of various diseases of the nasal mucosa by measuring sICAM-1 levels in nasal secretions using sandwich ELISA. Soluble ICAM-1 levels in patients with allergic rhinitis and nasal polyposis did not increase with respect to healthy controls, but patients with chronic sinusitis had higher sICAM-1 levels. Soluble ICAM-1 levels also increased in patients with allergic rhinitis after a provocation test with the specific allergen. These results show that ICAM-1 is involved in the pathogenesis of chronic sinusitis and allergic rhinitis.
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