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  • Title: Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
    Author: Akagi T, Ono H, Tsuchida N, Shimotohno K.
    Journal: FEBS Lett; 1997 Apr 14; 406(3):263-6. PubMed ID: 9136898.
    Abstract:
    The expression and function of p53 tumor suppressor protein was investigated in T-cells immortalized by the Tax1 protein of HTLV-I. Conformationally wild-type p53 was expressed at elevated levels in Tax1-immortalized T-cells by post-transcriptional mechanisms when compared with normal T-cells. Luciferase assays with a reporter plasmid containing p53-binding sites revealed an impairment in the transactivating function of p53 in Tax1-immortalized T-cells. Our results suggest an important role for Tax1 in the aberrant expression and function of p53 observed in many HTLV-I transformed cells.
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