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  • Title: Cellular immune reactions directed against Toxoplasma gondii with special emphasis on the central nervous system.
    Author: Däubener W, Hadding U.
    Journal: Med Microbiol Immunol; 1997 Mar; 185(4):195-206. PubMed ID: 9138291.
    Abstract:
    Toxoplasma gondii is an obligate intracellular parasite which, after primary infection of humans, is maintained in a dormant state by the host cellular immune system. In the event of an acquired immunosuppression, those parasites surviving as dormant cysts in the host may undergo a change in status, proliferate and cause a life-threatening toxoplasmic encephalitis. Over the last decade much knowledge has accumulated concerning the immune response against T. gondii. This review focuses attention particularly on the anti-parasitic effector mechanisms and the cellular immune reactions in the central nervous system during the course of reactivated toxoplasmic encephalitis.
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