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  • Title: [Modification of cytochrome P-450 apoenzyme during its oxidative self-inactivation in a reconstituted mono-oxygenase system].
    Author: Zgoda VG, Karuzina II, Nikitiuk OV, Archakov AI.
    Journal: Vopr Med Khim; 1996; 42(3):203-10. PubMed ID: 9139451.
    Abstract:
    The hemoprotein self-inactivation is accompanied by oxidation of all-groups, carbonyl group formation, changes in aggregate state and apoenzyme polymerization. It is probable that heme loss and oxidative modification of apoenzyme is a important step in regulation of P450 decay in cell.
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