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  • Title: [An immunohistochemical study of the expression of the oncoprotein p53 in astrocytic gliomas of the cerebral hemispheres].
    Author: Korshunov AG, Sycheva RV.
    Journal: Arkh Patol; 1996; 58(6):37-42. PubMed ID: 9139592.
    Abstract:
    p53 oncoprotein was studied in 80 astrocytic gliomas of the hemispheres and nuclear expression of this oncoprotein was found in 90% of the tumors this indicating high specificity of the reaction. A tendency to growing oncoprotein expression was found at different stages of malignant transformation showing feasibility of clonal expansion of cells with gene p53 mutation. High variability of the oncoprotein p53 immunoreactivity is characteristic of glioblastomas this suggesting genotypic polymorphism of gliomas of high grade malignancy. The lowest expression of the p53 oncoprotein was in gliosarcomas suggesting mechanism other than mutation. A stable link between the p53 oncoprotein expression and the proliferating cells nuclei antigen was not observed. This finding confirms an independent character of various progression features of the tumor.
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