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  • Title: [Therapy of hypertension with dimapres. Studies on the effect of the anti-hypertensive drug dimapres in newly adjusted and pretreated hypertensive patients].
    Author: Engelking H.
    Journal: Fortschr Med; 1977 Oct 06; 95(37):2263-6. PubMed ID: 914180.
    Abstract:
    41 hypertensive patients were treated with the new anti-hypertensive agent dimapres (1 tablet contains 0.150 mg clonidine and 2.5 mg cyclothiazide). 20 patients had not been treated before, 17 had reserpine-saluretic-combinations and 4 alpha-methyldopa. The dose of the medicament was adapted to the particular requirements of the individual patient and lay between 2 X 1/2 and 3 X 1 tablet daily. After conspicuously high blood pressure readings at the first examination, the previously treated patients showed almost normal blood pressures after discontinuation of the therapy and 2-3 days acclimatisation, while the untreated patients showed pressures slightly above normal. The preparation was well tolerated and normal blood pressures could be obtained with dimapres in all patients. Changing over from other preparations presented no problems. Exercise tolerance tests showed that there was less tendency for the blood pressure to rise to any great height during treatment with dimapres. The patients could tolerate effort better. dimapres reduces the raised reactivity to external stimuli in the hypertensive patient to a normal level.
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