These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Competition between polyanions in glomerular binding and renal clearance.
    Author: Burne MJ, Vyas SV, Smit MF, Pratt LM, Comper WD.
    Journal: Arch Biochem Biophys; 1997 Apr 15; 340(2):257-64. PubMed ID: 9143329.
    Abstract:
    This study tests the hypothesis that exogenous polyanions may accumulate in the glomerular capillary wall and thereby provide fixed negative charges that will be effective, through electrostatic interactions, in governing the transcapillary transport of charged molecules. We have tested the effects of high concentrations of dextran sulfate, heparin, and orosomucoid on the fractional clearance of albumin and dextran sulfate using the isolated perfused kidney technique. We demonstrate that all these exogenous polyanions are without effect on the fractional clearance of albumin. Augmentation of glomerular charge through the binding of dextran sulfate or orosomucoid is very small compared to the charge augmentation by albumin. These results agree with previous studies which demonstrate that electrostatic interactions governing glomerular transcapillary wall transport are negligible. This study also demonstrates that there is no plausible correlation between the fixed negative charge contributed by endogenous metabolically labeled glomerular heparan sulfate and the manifestation of apparent charge selectivity as determined with dextran sulfate. The results are also consistent with previous studies that the renal processing of both dextran sulfate and albumin is associated with specific cellular uptake.
    [Abstract] [Full Text] [Related] [New Search]