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  • Title: Oral contraceptives and riboflavin nutriture.
    Author: Guggenheim K, Segal S.
    Journal: Int J Vitam Nutr Res; 1977; 47(3):234-5. PubMed ID: 914458.
    Abstract:
    Riboflavin excretion in relation to creatinine and the activation coefficient of erythrocyte glutathione reductase (EGR) was studied in 27 women using oral contraceptives for 2-24 months and 12 nonusers. 21 subjects took alpha-norgesterol (.25 mg) and ethinyl estradiol (.05 mg), and 6 women took norethisterone acetate (1 mg) and ethinyl estradiol (.05 mg). Neither EGR activity nor riboflavin excretion of women using oral contraceptives differed significantly from the untreated group. Riboflavin excretion of 24 women using oral contraceptives and all control subjects was acceptable or high ( 80 mcg/gm creatinine) and 25 women using oral contraceptives and 10 control subjects had an activation coefficient of 1.2, which is acceptable. This would suggest that oral contraceptives have no detrimental effect on riboflavin metabolism in women with satisfactory riboflavin nutrition.
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