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  • Title: Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist tADA.
    Author: Klein J, Reymann KG, Riedel G.
    Journal: Neuropharmacology; 1997 Feb; 36(2):261-3. PubMed ID: 9144664.
    Abstract:
    In hippocampal slices taken from 8-day-old rats, trans-azetidine-2,4-dicarboxylic acid (tADA), a novel glutamatergic agonist acting preferentially at class I mGluR receptors, activates phosphoinositide and phosphatidylcholine hydrolysis with widely different potencies. Inositol phosphate formation was maximally increased at 10 microM tADA (EC50: 1.2 microM), while phospholipase D activation was observed at a tADA concentration of 1 mM. This is the first report of a tADA-induced phospholipase D activity.
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