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  • Title: In-vitro and in-vivo activities of DW-116, a new fluoroquinolone.
    Author: Choi KH, Hong JS, Kim SK, Lee DK, Yoon SJ, Choi EC.
    Journal: J Antimicrob Chemother; 1997 Apr; 39(4):509-14. PubMed ID: 9145824.
    Abstract:
    DW-116 is a novel fluoroquinolone that was two- to four-fold more active than rufloxacin and less active than sparfloxacin, ciprofloxacin and ofloxacin against Gram-positive bacteria in vitro. Against Gram-positive and Gram-negative bacteria, the in-vivo activity of DW-116 was similar or slightly greater than that of rufloxacin and less than that of sparfloxacin, ciprofloxacin and ofloxacin. ED50 (50% effective dose) values for DW-116 did not correlate with in-vitro MICs.
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