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  • Title: In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria.
    Author: Schülin T, Wennersten CB, Moellering RC, Eliopoulos GM.
    Journal: Antimicrob Agents Chemother; 1997 May; 41(5):1196-202. PubMed ID: 9145901.
    Abstract:
    The comparative in vitro activity of RU 64004 (also known as HMR 3004), a new ketolide antibiotic, was tested by agar dilution against approximately 500 gram-positive organisms, including multiply resistant enterococci, streptococci, and staphylococci. All streptococci were inhibited by < or = 1 microg of RU 64004 per ml. The ketolide was more potent than other macrolides against erythromycin A-susceptible staphylococci and was generally more potent than clindamycin against erythromycin A-resistant strains susceptible to this agent. Clindamycin-resistant staphylococci (MIC, > 128 microg/ml) proved resistant to the ketolide, but some erythromycin A- and clindamycin-resistant enterococci remained susceptible to RU 64004.
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