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  • Title: [The study of the in vitro effect of selenium on formation of active oxygen species and lipid peroxidation in rat liver microsomes].
    Author: Lashneva NV, Karge E, Knells U, Klinger V, Splinter FK, Tutel'ian VA.
    Journal: Vopr Med Khim; 1996; 42(2):119-24. PubMed ID: 9148594.
    Abstract:
    In vitro influence of sodium selenite on cytochrome P-450-dependent formation of active oxygen species on lipid peroxidation (LPO) in rat liver microsomes was studied. Sodium selenite (10(-6)-10(-3) M) did not influence rates of NADPH/Fe-induced formation of active oxygen species (O2.-, OH., H2O2) and NAPDH-dependent LPO. Only at 10(-3) M selenite caused significant decrease in production of hydrogen peroxide in microsomes. Data obtained suggest that sodium selenite at physiological concentrations does not influence formation of active oxygen species by cytochrome P-450 and the rate of enzymatic LPO in rat liver microsomes.
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