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  • Title: Monitoring fluid absorption using 1% ethanol-tagged glycine during operative hysteroscopy.
    Author: Molnar BG, Magos AL, Kay J.
    Journal: J Am Assoc Gynecol Laparosc; 1997 May; 4(3):357-62. PubMed ID: 9154786.
    Abstract:
    STUDY OBJECTIVE: To assess the value of expired breath ethanol as a marker of irrigating fluid absorption during hysteroscopic surgery using 1% ethanol-tagged 1.5% glycine. DESIGN: Prospective analysis. SETTING: Endoscopy training center of a university hospital. PATIENTS: Forty-eight women undergoing major hysteroscopic surgery for menorrhagia (40 transcervical endometrial resections, 8 rollerball endometrial ablations). INTERVENTIONS: Expired breath ethanol and venous blood samples were taken before and at 10-minute intervals during surgery. Volumetric absorption of irrigating fluid was checked at the same time. MEASUREMENTS AND MAIN RESULTS: Expired breath ethanol concentration, serum ethanol, several biochemical variables, and volume of absorbed irrigating fluid (direct and indirect) were measured. There was a linear positive correlation (r = 0.86, p <0.001) between direct vascular absorption of the irrigating fluid and expired breath ethanol concentration. Prediction can be given with 95% confidence that if the alcolmeter reading is below 0.45%, the volume of irrigating fluid absorbed is below 2000 ml. No significant correlation was seen between expired breath ethanol and indirect fluid absorption. CONCLUSIONS: As it is not possible to distinguish direct and indirect fluid absorption during hysteroscopic surgery, measuring expired breath ethanol is insufficient to assess overall fluid balance, and continuous volumetric assessment is still required.
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