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  • Title: Repeated 'superinduction' of interferon in human diploid fibroblast cultures.
    Author: Wiranowska-Stewart M, Chudzio T, Stewart WE.
    Journal: J Gen Virol; 1977 Oct; 37(1):221-3. PubMed ID: 915483.
    Abstract:
    Human diploid fibroblast cultures induced to make interferon by the combination of polyriboinosinic acid-polyribocytidylic adic, cycloheximide and actinomycin D degenerate thereafter, owing to the irreversible nature of the inhibition induced by actinomycin D. However, cultures superinduced with the DNA-dependent RNA synthesis inhibitor 5,6-dichloro-I-beta-D-ribofuranosylbenzimadazole (DRB) survive, owing to the reversible nature of the inhibition induced by DRB, and can again be superinduced on several occasions.
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