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  • Title: [Mechanism on androgen-independent progression of prostate cancer].
    Author: Shimazaki J, Akakura K, Furuya Y, Ito H.
    Journal: Nihon Rinsho; 1997 May; 55(5):1143-8. PubMed ID: 9155166.
    Abstract:
    Eighty percent of prostate cancer with metastasis respond to androgen ablasion, showing initial androgen-sensitive growth. However, more than half of responders gradually loses dependency up to 5 years. Animal experiments reveal that loss of androgen sensitivity is attributable to complex reasons; adaptation, paracrine control by other androgen-independent tissues, genetic changes and mutation of androgen receptor. Most important event is explained from alteration of expression on oncogenes and suppressor genes. Counterplan of the progression was discussed.
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