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  • Title: [Effect of various perfusion temperature regimens in heart surgery with extracorporeal circulation on glutathione levels and activity of enzymes of glutathione metabolism in erythrocytes].
    Author: Korotkina RN, Smirnov LS, Karelin AA.
    Journal: Patol Fiziol Eksp Ter; 1997; (1):8-10. PubMed ID: 9157386.
    Abstract:
    The level of glutathione and the activity of its exchange enzymes (glutathione reductase, glutathione-S-transferase, glutathione peroxidase), the content of malonic dialdehyde were studied in the red blood levels of 70 patients operated on under hypothermal perfusion for correction of acquired cardiac diseases. The plasma concentrations of myoglobin were also measured. There was a relationship of the time course of changes in the parameters in question to the depth of the body's cooling during surgical interventions. Shallow hypothermia (30-34 degrees C) caused a compensatory increase in the activity of glutathione peroxidase (by more than 30%) and in the concentration of glutathione (by more than 60%) at the cooling stage. Moderate hypothermia (26-29 degrees C) produced no impact on the level of glutathione and the activity of its exchange enzymes while deeper hypothermia (25 degrees C or below) induced decreases in the levels of glutathione (by more than 30 degrees C) and suppressed the activity of all the tested enzymes of its exchange. At the same time there are elevated concentrations of malonic dialdehyde at the warming-up stage and during early postperfusion. Myoglobin washing into plasma occurs under all temperature conditions of perfusion at the warming-up stages and in the early postperfusion period, but it is most profound in deeper hypothermia, which is caused by the toxic effect of oxygen whose plasma solubility increases with lowered temperatures.
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