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  • Title: Comparative study of uterine morphogenesis and protein secretion in neonatal White crossbred and Meishan gilts.
    Author: Christenson RK, Bartol FF, Vallet JL, Wiley AA, Spencer TE.
    Journal: Biol Reprod; 1997 May; 56(5):1112-9. PubMed ID: 9160708.
    Abstract:
    Thirty-five crossbred and 22 Meishan contemporary gilts were necropsied on Day 1, 14, 28, 42, or 56 of age (birth = Day 0). At necropsy, a cross section of one uterine horn was fixed for histomorphometric study, and minced uterine tissue was cultured with 50 muCi [3H]leucine. Secreted proteins were identified by two-dimensional PAGE, fluorography, and incorporation of radioactivity. Body weights at necropsy were similar for the two breeds and increased (p < 0.01) between Days 1 and 56 of age. Ovarian and uterine weights, as well as histomorphometric areas, were similar for the two breeds on Day 1 but increased markedly (p < 0.01) in Meishan gilts on Day 56. In gilts of both breeds, secretion of uterine proteins 1 (M(r) x 10(-3)/pI; 45/6.0), 2a and 2b (doublet, 25/6.2), and 3 (20/5.5) increased in association with endometrial gland development. A fourth protein (97/4.0) was observed in gilts of both breeds but was more abundant in Meishan; a fifth protein (13/6.0) was detected only in crossbred gilts on Day 56. Although specific regulatory roles for locally produced uterine proteins remain to be defined, the increase in specific uterine proteins and breed differences in uterine protein secretion suggest that uterine proteins may influence early uterine development.
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