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  • Title: [The effect of substances with nootropic activity on oxidative phosphorylation in brain mitochondria in acute craniocerebral trauma].
    Author: Novikov VE, Kovaleva LA.
    Journal: Eksp Klin Farmakol; 1997; 60(1):59-61. PubMed ID: 9162289.
    Abstract:
    An open craniocerebral trauma was simulated in rat experiments. Oxidative phosphorylation in the brain mitochondria was studied by polygraphy 24 h after the trauma. It was found that trauma to the brain leads to inhibition of respiration in mitochondria in various metabolic states. Nooglutil in a dose of 50 mg/kg prevents these changes. Nooglutil is more effective than picamilon (500 mg/kg) and piriditol (100 mg/kg).
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