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  • Title: [The system of hemostasis in experimental liver transplantation].
    Author: Zhidkov IL, Michailov IE, Broun NK, Smirnova LA, Buianov VV, Eramishantsev AK.
    Journal: Khirurgiia (Mosk); 1997; (2):35-8. PubMed ID: 9162767.
    Abstract:
    The status of haemostatic factors in 28 pigs after orthotopic liver transplantation was evaluated. The major changes took place in fibrinolytic system during the "non-liver" stage: rapid increase of fibrinolytic activity, plasmin activity, plasmin activator activity. From the moment of blood supply restoration to a transplanted liver the tendency to normalisation of fibrinolysis was detected. The deficiency of plasma haemostatic factors and platelets has increased during all the follow-up period and should be corrected in time. The following principles of corrective therapy are formulated: inhibition of fibrinolysis, correction of antithrombin-3 and blood clotting factors. Correction of haemostasis should be done in "pre-non-liver" period and later in "non-liver" reperfusion periods.
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