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  • Title: Different human tenascin-C variants in the extracellular matrix of cultured human fibroblasts.
    Author: Siri A, Allemanni G, Gaggero B, Zardi L.
    Journal: Biochem Cell Biol; 1996; 74(6):863-6. PubMed ID: 9164654.
    Abstract:
    Using an immunoadsorbent prepared with a monoclonal antibody specific for the high molecular mass isoform of human tenascin-C, we purified tenascin-C molecules containing at least one large subunit from the extracellular matrix of cultured normal human fibroblasts. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis and immunoblotting analyses have shown that both high and low molecular mass subunits are present in these tenascin-C preparations. Because the monoclonal antibody used is able to bind only the high molecular mass isoform, the present data show that part of the tenascin-C present in the fibroblast extracellular matrix is made up of heterohexameric molecules.
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