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  • Title: Phase III trials of toremifene vs tamoxifen.
    Author: Gams R.
    Journal: Oncology (Williston Park); 1997 May; 11(5 Suppl 4):23-8. PubMed ID: 9165503.
    Abstract:
    Three pivotal phase III trials conducted in North America and Europe served as the basis for the application for approval of toremifene (Fareston) by the FDA. These trials demonstrated that 60 mg/d of toremifene is safe and effective in the treatment of advanced breast cancer in postmenopausal women. The studies also indicated that, on the basis of antitumor efficacy, as well as safety, toremifene is at least equivalent to tamoxifen and may have some long-term advantages.
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