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  • Title: DNA flow cytometry: a predictor of a high-risk group in cervical cancer.
    Author: Anton M, Nenutil R, Rejthar A, Kopecny J, Ptackova B, Zaloudik J.
    Journal: Cancer Detect Prev; 1997; 21(3):242-6. PubMed ID: 9167041.
    Abstract:
    We studied the relationship between the 5-year disease-free interval or the occurrence of distant metastases, and the flow cytometric nuclear DNA content in a group of 55 patients treated by radiation for squamous cell carcinoma of the uterine cervix, stages Ib-IIIb (FIGO). The diploid DNA content was associated with a better prognosis and a lower incidence of distant metastases, while aneuploid tumors tended to be prognostically unfavorable and had distant metastases more often. We consider the flow cytometric nuclear DNA content a prospective prognostic parameter in squamous cell carcinoma of the uterine cervix treated by radiotherapy.
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