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  • Title: Inhibition of lipid peroxidation by N-acetylserotonin and its role in retinal physiology.
    Author: Longoni B, Pryor WA, Marchiafava P.
    Journal: Biochem Biophys Res Commun; 1997 Apr 28; 233(3):778-80. PubMed ID: 9168932.
    Abstract:
    N-Acetylserotonin (NAS) inhibits the peroxidation of linoleic acid induced by a water-soluble initiator, 2,2'-azobis(2-amidinopropane) (ABAP). Lipid peroxidation was detected by the formation of conjugated dienes, monitored spectrophotometrically at 236 nm. N-Acetylserotonin, at concentrations ranging from 200 nM to 20 microM, reduced the rate of ABAP-initiated lipid peroxidation in a concentration-dependent manner. The results of NAS-inhibited lipid peroxidation are compared to the antioxidant activities of melatonin, vitamin E, and a water-soluble vitamin E analog, Trolox. It is suggested that NAS acts as a physiological antioxidant in retinal photoreceptor cells.
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